She called the US President-elect a bully who humiliates others as she added,
"There was one performance this year that stunned me - it sank its hooks in my heart."
"Not because it was good; there was nothing good about it. But it was effective and it did its job. It made its intended audience laugh and show their teeth.
"It was that moment when the person asking to sit in the most respected seat in our country imitated a disabled reporter," she said, referring to a speech by Trump in 2015 when he mocked a disabled reporter for The New York Times.
"It kind of broke my heart when I saw it, and I still can't get it out of my head, because it wasn't in a movie. It was real life."
The Golden Globes being the first award ceremony of the year and the last high-profile Hollywood event before Trump's inauguration on 20th Jan, a shift in power that many in the entertainment industry have not been too happy with.
The Golden Globes were the last high-profile Hollywood event before Trump's inauguration on January 20, a transfer of power that many in the entertainment industry have bemoaned.
Though Trump flatly denied any such act of making fun of the reporter, Serge F. Kovaleski. "I was never mocking anyone.
"People keep saying I intended to mock the reporter's disability as if Meryl Streep and others could read my mind. I did no such thing," he said.
Trump also believes aside from Streep and her followers, he was confident other celebrities would turn out in strong numbers for his inauguration.
"We are going to have an unbelievable, perhaps record-setting turnout for the inauguration, and there will be plenty of movie and entertainment stars," Trump said. "All the dress shops are sold out in Washington. It's hard to find a great dress for this inauguration."
Apart from Streep, British actor Hugh Laurie and US comedian-host Jimmy Fallon, who hosted the awards ceremony, also poked fun at Trump.